Skip to contents

Concomitant Medications Analysis Dataset (ADCM)

Source: R/data.R
adcm.Rd

Synthetic CDISC ADaM Concomitant Medications (ADCM) dataset from study TFRM-2024-001. Contains one row per subject per concomitant medication. Used for:

  • Concomitant medications table (Table 14.4.1): subjects using each medication category and individual agent, by treatment arm

Medications reflect realistic co-morbidities in an elderly Alzheimer's population: hypertension, diabetes, pain, GI protection, and supplements are common. Medication use is independent of treatment assignment.

Usage

adcm

Format

A data frame with approximately 600 rows and 13 variables:

STUDYID

Study identifier

USUBJID

Unique subject identifier

ARM

Planned treatment arm

TRTA

Actual treatment arm

TRTAN

Actual treatment numeric code

AGE

Subject age

SEX

Subject sex

SAFFL

Safety population flag

CMDECOD

Decoded medication name (WHO Drug Dictionary-style, uppercase), e.g. "PARACETAMOL", "ATORVASTATIN", "VITAMIN D"

CMCAT

ATC-inspired medication category, e.g. "ANALGESICS", "ANTIHYPERTENSIVES", "LIPID MODIFYING AGENTS", "SUPPLEMENTS"

CMSTDT

Concomitant medication start date

CMENDT

Concomitant medication end date (NA if ongoing at data cut)

ONGOING

Logical; TRUE if medication was ongoing at data cut

Source

Synthetic data generated in data-raw/create_adam_datasets.R.

Examples

# Unique subjects per medication category (for conmed table)
tapply(adcm$USUBJID, adcm$CMCAT, function(x) length(unique(x)))
#>              ANALGESICS          ANTICOAGULANTS           ANTIDIABETICS 
#>                      74                      11                      40 
#>       ANTIHYPERTENSIVES             ANXIOLYTICS               DIURETICS 
#>                      94                      18                      30 
#> GASTROINTESTINAL AGENTS  LIPID MODIFYING AGENTS             SUPPLEMENTS 
#>                      41                      65                      88 
#>          THYROID AGENTS 
#>                      23 

# Most common individual medications
sort(table(adcm$CMDECOD), decreasing = TRUE)
#> 
#>        AMLODIPINE         VITAMIN D      ATORVASTATIN           ASPIRIN 
#>                56                54                45                42 
#>        LISINOPRIL       PARACETAMOL CALCIUM CARBONATE     MULTIVITAMINS 
#>                40                36                35                34 
#>        FUROSEMIDE         METFORMIN        METOPROLOL        OMEPRAZOLE 
#>                30                30                29                27 
#>       SIMVASTATIN     LEVOTHYROXINE          ATENOLOL         LORAZEPAM 
#>                25                23                18                18 
#>      PANTOPRAZOLE         IBUPROFEN         GLIPIZIDE          WARFARIN 
#>                18                14                12                11 

# Subjects on lipid-modifying agents, by arm
statins <- subset(adcm, CMCAT == "LIPID MODIFYING AGENTS")
table(statins$ARM)
#> 
#>        Placebo Zomerane 100mg  Zomerane 50mg 
#>             19             23             28